OUR TARGET INDICATIONS

THERMAL PLASMA-GENERATED NITRIC OXIDE THERAPY

Combining the benefits of nitric oxide (NO) with the power of plasma, our IonoJet™ platform has potential application across a broad spectrum of disease states including wound healing, combatting infection and reducing pain and inflammation.

The following is a summary of the medical fields within which we intend to explore the use of the therapy generated by the Ionojet™ device, or in certain fields, by adaptations to the reengineered Ionojet™. It is anticipated that for all of the fields set forth below our reengineered Ionojet™ device will be used to generate a plasma/NO stream to be delivered topically to the patient, with the exception of the treatment of dental infections and upper respiratory infections, which will require adaptations to the reengineered Ionojet.

Wounds — Our initial objective is to seek regulatory approval for the use of our therapy to treat patients suffering from diabetic foot ulcers. At this time, we have completed the feasibility studies for the treatment of diabetic foot ulcers. An IRB approved observational study evaluating the promotion of wound-healing and control of infection in the treatment of various chronic wounds, including diabetic foot ulcers, was completed in 2013. We intend to evaluate the possible use of our therapy to treat other wounds including but not limited to acute wounds, venous leg ulcers, pressure ulcers, post-surgical wounds, thermal burns and radiation burns.

Anti-infective —We plan to investigate the treatment of various infected conditions including but not limited to onychomycosis (toenail fungus), surgical site infections and chronic infections. Infected pacemaker and defibrillator implant wounds and infected orthopaedic implant wounds were the subject of two IRB-approved observational studies to examine the effect of plasma/NO in treating these infections.

Dermal Therapeutics — We believe that our therapy has the potential to be used as a treatment for various dermatological conditions, including but not limited to chronic papulopustular and conglobate acne, cellulitis and plantar and viral warts.

Musculoskeletal — We intend to explore the treatment of various musculoskeletal conditions including but not limited to rheumatoid arthritis, an autoimmune and inflammatory disease, osteo-arthritis, tendinitis, fasciitis and sports injuries.

Cosmetic — We also intend to explore the use of our therapy for various cosmetic applications including but not limited to treatment of alopecia.

Dental Infections — We intend to explore the use of our therapy, employing an adaptation of the reengineered Ionojet™ device, for various dental indications, including but not limited to periodontitis, gingivitis, implantitis and surgical extraction infections.

Respiratory Tract Infections — We intend to explore the treatment of various viral and bacterial upper respiratory infections using an adaptation of the reengineered Ionojet™ device.